Mitigation of oxidative stress and testicular damage by Barringtonia racemosa aqueous extract in streptozotocin-nicotinamide induced diabetic rats

Diabetes mellitus is a chronic metabolic disorder associated with various complications which include derangement in male reproductive functions. Barringtonia racemosa, has been studied widely as a complementary intervention in managing diabetes mellitus. However, the effect of B. racemosa on the male reproductive system is yet to be elucidated. Therefore, this study aimed to investigate the potential protective role of B. racemosa on male reproductive functions in type 2 diabetes mellitus (T2DM). The diabetic rats were administered 250 and 500 mg/kg/day body weight of B. racemosa aqueous extracts (BRAE) for 42 days. Fasting blood glucose was measured at the end of the experimental duration. Following sacrifice, the testes sections were examined for histopathological changes, and sperm count was assessed for further evaluation. Additionally, the testes homogenates were analyzed to determine antioxidant activity levels. Administration of BRAE ameliorated fasting blood glucose levels reduced structural damage to the testes, and improved sperm count. These findings were further supported by decreased lipid peroxidation and enhanced antioxidant enzyme activities in the testes of diabetic rats treated with BRAE. This study underscores the potential of BRAE, particularly at 250 mg/kg, as a promising candidate for managing diabetes-induced male infertility.

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